Distinct temporal integration of noradrenaline signaling by astrocytic second messengers during vigilance.

ABSTRACT: Astrocytes may function as mediators of the impact of noradrenaline on neuronal function. Activation of glial α1-adrenergic receptors triggers rapid astrocytic Ca²⁺ elevation and facilitates synaptic plasticity, while activation of β-adrenergic receptors elevates cAMP levels and modulates memory consolidation. However, the dynamics of these processes in behaving mice remain unexplored, as do the interactions between the distinct second messenger pathways. Here we simultaneously monitored astrocytic Ca²⁺ and cAMP and demonstrate that astrocytic second messengers are regulated in a temporally distinct manner. In behaving mice, we found that while an abrupt facial air puff triggered transient increases in noradrenaline release and large cytosolic astrocytic Ca²⁺

SUBMITTER: Oe Y 

PROVIDER: S-EPMC6981284 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature