Profiling of O-acetylated Gangliosides Expressed in Neuroectoderm Derived Cells.

ABSTRACT: The expression and biological functions of oncofetal markers GD2 and GD3 were extensively studied in neuroectoderm-derived cancers in order to characterize their potential as therapeutic targets. Using immunological approaches, we previously identified GD3, GD2, and OAcGD2 expression in breast cancer (BC) cell lines. However, antibodies specific for O-acetylated gangliosides are not exempt of limitations, as they only provide information on the expression of a limited set of O-acetylated ganglioside species. Consequently, the aim of the present study was to use structural approaches in order to apprehend ganglioside diversity in melanoma, neuroblastoma, and breast cancer cells, focusing on O-acetylated species that are usually lost under alkaline conditions and require specific analytical

SUBMITTER: Cavdarli S 

PROVIDER: S-EPMC6981417 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature