On-Membrane Dynamic Interplay between Anti-GM1 IgG Antibodies and Complement Component C1q.

ABSTRACT: Guillain-Barré syndrome, an autoimmune neuropathy characterized by acute limb weakness, is often preceded by Campylobacter jejuni infection. Molecular mimicry exists between the bacterial lipo-oligosaccharide and human ganglioside. Such C. jejuni infection induces production of immunoglobulin G1 (IgG1) autoantibodies against GM1 and causes complement-mediated motor nerve injury. For elucidating the molecular mechanisms linking autoantigen recognition and complement activation, we characterized the dynamic interactions of anti-GM1 IgG autoantibodies on ganglioside-incorporated membranes. Using high-speed atomic force microscopy, we found that the IgG molecules assemble into a hexameric ring structure on the membranes depending on their specific interactions with GM1. Complemen

SUBMITTER: Yanaka S 

PROVIDER: S-EPMC6981440 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature