TEMPO-Nanocellulose/Ca²⁺ Hydrogels: Ibuprofen Drug Diffusion and In Vitro Cytocompatibility.

ABSTRACT: Stable hydrogels with tunable rheological properties were prepared by adding Ca²⁺ ions to aqueous dispersions of 2,2,6,6-tetramethylpiperidine 1-oxyl (TEMPO)-oxidized and ultra-sonicated cellulose nanofibers (TOUS-CNFs). The gelation occurred by interaction among polyvalent cations and the carboxylic units introduced on TOUS-CNFs during the oxidation process. Both dynamic viscosity values and pseudoplastic rheological behaviour increased by increasing the Ca²⁺ concentration, confirming the cross-linking action of the bivalent cation. The hydrogels were proved to be suitable controlled release systems by measuring the diffusion coefficient of a drug model (ibuprofen, IB) by high-resolution magic angle spinning (HR-MAS) nuclear magnetic resonance (NMR) spectroscopy. IB

SUBMITTER: Fiorati A 

PROVIDER: S-EPMC6981511 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature