Dihydrochalcone Derivatives from Populus balsamifera L. Buds for the Treatment of Psoriasis.

ABSTRACT: Psoriasis is a skin disorder characterized by epidermal hyperplasia, hyperkeratosis, and inflammation. The treatments currently available on the market only improve patients' quality of life and are associated with undesirable side effects. Thus, research leading to the development of new, effective, and safer therapeutic agents is still relevant. Populus balsamifera L. buds were used traditionally by Native Americans to treat various skin pathologies such as eczema and psoriasis. In this study, the antipsoriatic activities of dihydrochalcone derivatives from Populus balsamifera L. buds, known as balsacones, were investigated. The experiments were performed in vitro using a psoriatic skin substitute model. Also, anti-inflammatory and antioxidant activities were investigated. The tested bal

SUBMITTER: Belanger A 

PROVIDER: S-EPMC6981943 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature