Structural Characterization of the CD44 Stem Region for Standard and Cancer-Associated Isoforms.

ABSTRACT: CD44 is widely expressed in most vertebrate cells, whereas the expression of CD44v6 is restricted to only a few tissues and has been considered to be associated with tumor progression and metastasis. Thus, CD44v6 has been recognized as a promising prognostic biomarker and therapeutic target for various cancers for more than a decade. However, despite many experimental studies, the structural dynamics and differences between CD44s and CD44v6, particularly in their stem region, still remain elusive. Here, a computational study was conducted to address these problems. We found that the stem of CD44s adopted predominantly two conformations, one featuring antiparallel β-sheets and the other featuring parallel β-sheets, whereas the stem of CD44v6 adopted mainly one conformation with relatively h

SUBMITTER: Chen KL 

PROVIDER: S-EPMC6982006 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature