Cost-Effective Detection of Perfluoroalkyl Carboxylic Acids with Gas Chromatography: Optimization of Derivatization Approaches and Method Validation.

ABSTRACT: The reliable quantification of perfluoroalkyl carboxylic acids (PFCAs) in environmental samples like surface water by using gas chromatography (GC) remains challenging because the polar PFCAs call for derivatization before injection and problems involving the integration of sample pretreatment and derivatization procedures. Here we proposed a cost-effective method for the GC based determination of C4-C12 PFCAs in surface water samples by integrating solid phase extraction and PFCAs anilide derivatization. First, we assessed the performance of different PFCAs derivatization methods, namely esterification and amidation. Esterification was unable to derivatize C4-C6 PFCAs. On the contrary, amidation procedures by using 2,4-difluoroaniline (DFA) and N,N'-dicyclohexylcarbodiimide (DCC) could su

SUBMITTER: Li Z 

PROVIDER: S-EPMC6982026 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature