A Single Cell but Many Different Transcripts: A Journey into the World of Long Non-Coding RNAs.

ABSTRACT: In late 2012 it was evidenced that most of the human genome is transcribed but only a small percentage of the transcripts are translated. This observation supported the importance of non-coding RNAs and it was confirmed in several organisms. The most abundant non-translated transcripts are long non-coding RNAs (lncRNAs). In contrast to protein-coding RNAs, they show a more cell-specific expression. To understand the function of lncRNAs, it is fundamental to investigate in which cells they are preferentially expressed and to detect their subcellular localization. Recent improvements of techniques that localize single RNA molecules in tissues like single-cell RNA sequencing and fluorescence amplification methods have given a considerable boost in the knowledge of the lncRNA functions. In rec

SUBMITTER: Alessio E 

PROVIDER: S-EPMC6982300 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature