GABAergic Restriction of Network Dynamics Regulates Interneuron Survival in the Developing Cortex.

ABSTRACT: During neonatal development, sensory cortices generate spontaneous activity patterns shaped by both sensory experience and intrinsic influences. How these patterns contribute to the assembly of neuronal circuits is not clearly understood. Using longitudinal in vivo calcium imaging in un-anesthetized mouse pups, we show that spatially segregated functional assemblies composed of interneurons and pyramidal cells are prominent in the somatosensory cortex by postnatal day (P) 7. Both reduction of GABA release and synaptic inputs onto pyramidal cells erode the emergence of functional topography, leading to increased network synchrony. This aberrant pattern effectively blocks interneuron apoptosis, causing increased survival of parvalbumin and somatostatin interneurons. Furthermore, the effect o

SUBMITTER: Duan ZRS 

PROVIDER: S-EPMC6982374 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature