High-salt diet does not boost neuroinflammation and neurodegeneration in a model of α-synucleinopathy.

ABSTRACT: AIM:Pre-clinical studies in models of multiple sclerosis and other inflammatory disorders suggest that high-salt diet may induce activation of the immune system and potentiate inflammation. However, high-salt diet constitutes a common non-pharmacological intervention to treat autonomic problems in synucleinopathies such as Parkinson's disease and multiple system atrophy. Since neuroinflammation plays an important pathogenic role in these neurodegenerative disorders, we asked here whether high-salt diet may aggravate the disease phenotype in a transgenic model of multiple system atrophy. METHODS:Nine-month-old PLP-hαSyn and matched wildtype mice received normal or high-salt diet for a period of 3 months. Behavioral, histological, and molecular analyses were performed to evaluate the effect

SUBMITTER: Heras-Garvin A 

PROVIDER: S-EPMC6982394 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature