T cell receptor gene therapy targeting WT1 prevents acute myeloid leukemia relapse post-transplant.

ABSTRACT: Relapse after allogeneic hematopoietic cell transplantation (HCT) is the leading cause of death in patients with acute myeloid leukemia (AML) entering HCT with poor-risk features^1-3. When HCT does produce prolonged relapse-free survival, it commonly reflects graft-versus-leukemia effects mediated by donor T cells reactive with antigens on leukemic cells⁴. As graft T cells have not been selected for leukemia specificity and frequently recognize proteins expressed by many normal host tissues, graft-versus-leukemia effects are often accompanied by morbidity and mortality from graft-versus-host disease⁵. Thus, AML relapse risk might be more effectively reduced with T cells expressing receptors (TCRs) that target selected AML antigens⁶. We therefore i

SUBMITTER: Chapuis AG 

PROVIDER: S-EPMC6982533 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature