Effects of ondansetron on apamin-sensitive small conductance calcium-activated potassium currents in pacing-induced failing rabbit hearts.

ABSTRACT:

Background

Ondansetron, a widely prescribed antiemetic, has been implicated in drug-induced long QT syndrome. Recent patch clamp experiments have shown that ondansetron inhibits the apamin-sensitive small conductance calcium-activated potassium current (I_KAS).

Objective

The purpose of this study was to determine whether ondansetron causes action potential duration (APD) prolongation by I_KAS inhibition.

Methods

Optical mapping was performed in rabbit hearts with pacing-induced heart failure (HF) and in normal hearts before and after ondansetron (100 nM) infusion. APD at 80% repolarization (APD₈₀) and arrhythmia inducibility were determined. Additional studies with ondansetron were performed in normal hearts perfused with hypokalemic Tyr

SUBMITTER: Yin D 

PROVIDER: S-EPMC6982558 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature