Cross-Linking-Assisted Infection Reduction: A Randomized Clinical Trial Evaluating the Effect of Adjuvant Cross-Linking on Outcomes in Fungal Keratitis.

ABSTRACT:

Purpose

To determine if there is a benefit to adjuvant corneal crosslinking (CXL) and to compare natamycin versus amphotericin B for filamentous fungal keratitis.

Design

Outcome-masked, 2×2 factorial design, randomized controlled clinical trial.

Participants

Consecutive patients presenting with moderate vision loss from a smear-positive fungal ulcer at Aravind Eye Hospital, Madurai, India.

Methods

Study eyes were randomized to 1 of 4 treatment combinations using an adaptive randomization protocol. The treatment arms included (1) topical natamycin 5% alone, (2) topical natamycin 5% plus CXL, (3) topical amphotericin B 0.15% alone, and (4) topical amphotericin 0.15% plus CXL.

Main outcome measures

The primary outcome of the trial was microbiological cure a

SUBMITTER: Prajna NV 

PROVIDER: S-EPMC6982573 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature