Geometrical characterization of T cell receptor binding modes reveals class-specific binding to maximize access to antigen.

ABSTRACT: Recognition of antigenic peptides bound to major histocompatibility complex (MHC) proteins by αβ T cell receptors (TCRs) is a hallmark of T cell mediated immunity. Recent data suggest that variations in TCR binding geometry may influence T cell signaling, which could help explain outliers in relationships between physical parameters such as TCR-pMHC binding affinity and T cell function. Traditionally, TCR binding geometry has been described with simple descriptors such as the crossing angle, which quantifies what has become known as the TCR's diagonal binding mode. However, these descriptors often fail to reveal distinctions in binding geometry that are apparent through visual inspection. To provide a better framework for relating TCR structure to T cell function, we developed a comprehens

SUBMITTER: Singh NK 

PROVIDER: S-EPMC6982585 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature