Development and Calibration of a Dynamic HIV Transmission Model for 6 US Cities.

ABSTRACT: Background. Heterogeneity in HIV microepidemics across US cities necessitates locally oriented, combination implementation strategies to prioritize resources. We calibrated and validated a dynamic, compartmental HIV transmission model to establish a status quo treatment scenario, holding constant current levels of care for 6 US cities. Methods. Built off a comprehensive evidence synthesis, we adapted and extended a previously published model to replicate the transmission, progression, and clinical care for each microepidemic. We identified a common set of 17 calibration targets between 2012 and 2015 and used the Morris method to select the most influential parameters for calibration. We then applied the Nelder-Mead algorithm to iteratively calibrate the model to generate 2000

SUBMITTER: Zang X 

PROVIDER: S-EPMC6982595 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature