The effect of dust storm particles on single human lung cancer cells.

ABSTRACT: Exposure to dust particles during dust storms can lead to respiratory problems, diseases, and even death. The effect of dust particles at the cellular level is poorly understood. In this study, we investigated the impact that dust storm particles (Montmorillonite) have on human lung epithelial cells (A549) at the single cell level. Using live-cell imaging, we continuously followed individual cells after exposure to a wide range of concentrations of dust particles. We monitored the growth trajectory of each cell including number and timing of divisions, interaction with the dust particles, as well as time and mechanism of cell death. We found that individual cells show different cellular fates (survival or death) even in response to the same dust concentration. Cells that died interacted wi

SUBMITTER: Ardon-Dryer K 

PROVIDER: S-EPMC6982605 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature