Sex differences in Parkinson's disease presentation and progression.

ABSTRACT: INTRODUCTION:Females have a reduced risk of Parkinson's disease (PD). However, it is unclear if sex is a prognostic factor. We aimed to examine differences in presentation, physician- and patient-reported PD outcomes, and progression by sex in a large clinical cohort. METHODS:This study was a secondary analysis of a cohort of PD patients seen at a tertiary care center. Sociodemographic and clinical characteristics, treatment, care timing, and outcomes were examined by sex. Sex differences in progression of impairment, disability, and health-related quality of life (HRQoL) were tested with five-year piecewise linear mixed-effects models. A mediation analysis assessed drivers of sex differences. RESULTS:The study included 914 males and 549 females. Females had significantly less social suppo

SUBMITTER: Abraham DS 

PROVIDER: S-EPMC6982644 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature