Magnetic Cell Centrifuge Platform Performance Study with Different Microsieve Pore Geometries.

ABSTRACT: The detection and analysis of circulating tumor cells (CTCs) plays a crucial role in clinical practice. However, the heterogeneity and rarity of CTCs make their capture and separation from peripheral blood very difficult while maintaining their structural integrity and viability. We previously demonstrated the effectiveness of the Magnetic Cell Centrifuge Platform (MCCP), which combined the magnetic-labeling cell separation mechanism with the size-based method. In this paper, a comparison of the effectiveness of different microsieve pore geometries toward MCCP is demonstrated to improve the yield of the target cell capture. Firstly, models of a trapped cell with rectangular and circular pore geometries are presented to compare the contact force using finite element numerical simulations. T

SUBMITTER: Wu X 

PROVIDER: S-EPMC6983067 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature