Short-term exposures to particulate matter gamma radiation activities and biomarkers of systemic inflammation and endothelial activation in COPD patients.

ABSTRACT:

Background

We hypothesized that particulate matter (PM) gamma activity (gamma radiation associated with PM) is associated with systemic effects.

Objective

Examine short-term relationships between ambient and indoor exposures to PM gamma activities with systemic inflammation and endothelial activation in chronic obstructive pulmonary disease (COPD) patients.

Methods

In 85 COPD patients from Eastern Massachusetts, USA from 2012 to 2014, plasma C-reactive protein (CRP), interleukin-6 (IL-6), and soluble vascular cell adhesion molecule-1 (sVCAM-1) were measured seasonally up to four times. We used US EPA RadNet data measuring ambient gamma radiation attached to PM adjusted for background radiation, and estimated in-home gamma radiation exposures using the ratio of in-home

SUBMITTER: Huang S 

PROVIDER: S-EPMC6983292 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature