Multiparametric magnetic resonance imaging shows promising results to assess renal transplant dysfunction with fibrosis.

ABSTRACT: Here we assessed the diagnostic value of a quantitative multiparametric magnetic resonance imaging (mpMRI) protocol for evaluation of renal allograft dysfunction with fibrosis. Twenty-seven renal transplant patients, including 15 with stable functional allografts (eGFR mean 71.5 ml/min/1.73m²), and 12 with chronic dysfunction/established fibrosis (eGFR mean 30.1 ml/min/1.73m²), were enrolled in this prospective single-center study. Sixteen of the patients had renal biopsy (mean 150 days) before the MRI. All patients underwent mpMRI at 1.5T including intravoxel-incoherent motion diffusion-weighted imaging, diffusion tensor imaging, blood oxygen level dependent (BOLD R₂*) and T₁ quantification. True diffusion D, pseudodiffusion D*, perfusion fracti

SUBMITTER: Bane O 

PROVIDER: S-EPMC6983343 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature