Distress and anhedonia as predictors of depression treatment outcome: A secondary analysis of a randomized clinical trial.

ABSTRACT: Two core features of depression include depressed mood (heightened distress) and anhedonia (reduced pleasure). Despite their centrality to depression, studies have not examined their contribution to treatment outcomes in a randomized clinical trial providing mainstream treatments like antidepressant medications (ADM) and cognitive therapy (CT). We used baseline distress and anhedonia derived from a factor analysis of the Mood and Anxiety Symptom Questionnaire to predict remission and recovery in 433 individuals with recurrent/chronic major depressive disorder. Patients were provided with only ADM or both ADM and CT. Overall, higher baseline distress and anhedonia predicted longer times to remission within one year and recovery within three years. When controlling for treatment condition, d

SUBMITTER: Khazanov GK 

PROVIDER: S-EPMC6983353 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature