Bioderivatization as a concept for renewable production of chemicals that are toxic or poorly soluble in the liquid phase.

ABSTRACT: Bio-based production technologies may complement or replace petroleum-based production of chemicals, but they face a number of technical challenges, including product toxicity and/or water insolubility. Plants and microorganisms naturally biosynthesize chemicals that often are converted into derivatives with reduced toxicity or enhanced solubility. Inspired by this principle, we propose a bioderivatization strategy for biotechnological chemicals production, defined as purposeful biochemical derivatization of intended target molecules. As proof of principle, the effects of hydrophobic (e.g., esterification) and hydrophilic (e.g., glycosylation) bioderivatization strategies on the biosynthesis of a relatively toxic and poorly soluble chemical, 1-octanol, were evaluated in Escherichia coli

SUBMITTER: Sattayawat P 

PROVIDER: S-EPMC6983404 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature