Mitochondrial dysfunctions trigger the calcium signaling-dependent fungal multidrug resistance.

ABSTRACT: Drug resistance in fungal pathogens has risen steadily over the past decades due to long-term azole therapy or triazole usage in agriculture. Modification of the drug target protein to prevent drug binding is a major recognized route to induce drug resistance. However, mechanisms for nondrug target-induced resistance remain only loosely defined. Here, we explore the molecular mechanisms of multidrug resistance resulted from an efficient adaptation strategy for survival in drug environments in the human pathogen Aspergillus fumigatus We show that mutants conferring multidrug resistance are linked with mitochondrial dysfunction induced by defects in heme A biosynthesis. Comparison of the gene expression profiles between the drug-resistant mutants and the parental wild-type strain show

SUBMITTER: Li Y 

PROVIDER: S-EPMC6983421 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature