Unique and non-redundant function of csf1r paralogues in regulation and evolution of post-embryonic development of the zebrafish.

ABSTRACT: Evolution is replete with reuse of genes in different contexts, leading to multifunctional roles of signaling factors during development. Here, we explore osteoclast regulation during skeletal development through analysis of colony-stimulating factor 1 receptor (csf1r) function in the zebrafish. A primary role of Csf1r signaling is to regulate the proliferation, differentiation and function of myelomonocytic cells, including osteoclasts. We demonstrate the retention of two functional paralogues of csf1r in zebrafish. Mutant analysis indicates that the paralogues have shared, non-redundant roles in regulating osteoclast activity during the formation of the adult skeleton. csf1ra, however, has adopted unique roles in pigment cell patterning not seen in the second paralog

SUBMITTER: Caetano-Lopes J 

PROVIDER: S-EPMC6983717 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature