Aurora B functions at the apical surface after specialized cytokinesis during morphogenesis in C. elegans.

ABSTRACT: Although cytokinesis has been intensely studied, the way it is executed during development is not well understood, despite a long-standing appreciation that various aspects of cytokinesis vary across cell and tissue types. To address this, we investigated cytokinesis during the invariant Caenorhabditis elegans embryonic divisions and found several parameters that are altered at different stages in a reproducible manner. During early divisions, furrow ingression asymmetry and midbody inheritance is consistent, suggesting specific regulation of these events. During morphogenesis, we found several unexpected alterations to cytokinesis, including apical midbody migration in polarizing epithelial cells of the gut, pharynx and sensory neurons. Aurora B kinase, which is essential for several aspe

SUBMITTER: Bai X 

PROVIDER: S-EPMC6983721 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature