JNK signaling is required for proper tangential migration and laminar allocation of cortical interneurons.

ABSTRACT: The precise migration of cortical interneurons is essential for the formation and function of cortical circuits, and disruptions to this key developmental process are implicated in the etiology of complex neurodevelopmental disorders, including schizophrenia, autism and epilepsy. We have recently identified the Jun N-terminal kinase (JNK) pathway as an important mediator of cortical interneuron migration in mice, regulating the proper timing of interneuron arrival into the cortical rudiment. In the current study, we demonstrate a vital role for JNK signaling at later stages of corticogenesis, when interneurons transition from tangential to radial modes of migration. Pharmacological inhibition of JNK signaling in ex vivo slice cultures caused cortical interneurons to rapidly depart from mig

SUBMITTER: Myers AK 

PROVIDER: S-EPMC6983726 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature