Genome-wide association study of delay discounting in 23,217 adult research participants of European ancestry.

ABSTRACT: Delay discounting (DD), the tendency to discount the value of delayed versus current rewards, is elevated in a constellation of diseases and behavioral conditions. We performed a genome-wide association study of DD using 23,127 research participants of European ancestry. The most significantly associated single-nucleotide polymorphism was rs6528024 (P = 2.40 × 10^-8), which is located in an intron of the gene GPM6B. We also showed that 12% of the variance in DD was accounted for by genotype and that the genetic signature of DD overlapped with attention-deficit/hyperactivity disorder, schizophrenia, major depression, smoking, personality, cognition and body weight.

SUBMITTER: Sanchez-Roige S 

PROVIDER: S-EPMC6984001 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature