Methylated DNA in Pancreatic Juice Distinguishes Patients With Pancreatic Cancer From Controls.

ABSTRACT:

Background & aims

Precursors of pancreatic cancer arise in the ductal epithelium; markers exfoliated into pancreatic juice might be used to detect high-grade dysplasia (HGD) and cancer. Specific methylated DNA sequences in pancreatic tissue have been associated with adenocarcinoma. We analyzed these methylated DNA markers (MDMs) in pancreatic juice samples from patients with pancreatic ductal adenocarcinomas (PDACs) or intraductal papillary mucinous neoplasms (IPMNs) with HGD (cases), and assessed their ability to discriminate these patients from individuals without dysplasia or with IPMNs with low-grade dysplasia (controls).

Methods

We obtained pancreatic juice samples from 38 patients (35 with biopsy-proven PDAC or pancreatic cystic lesions with invasive cancer and 3 with

SUBMITTER: Majumder S 

PROVIDER: S-EPMC6984349 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature