The cellular prion protein promotes neuronal regeneration after acute nasotoxic injury.

ABSTRACT: Adult neurogenesis, analogous to early development, is comprised of several, often concomitant, processes including proliferation, differentiation, and formation of synaptic connections. However, due to continual, asynchronous turn-over, newly-born adult olfactory sensory neurons (OSNs) must integrate into existing circuitry. Additionally, OSNs express high levels of cellular prion protein (PrP^C), particularly in the axon, which implies a role in this cell type. The cellular prion has been shown to be important for proper adult OSN neurogenesis primarily by stabilizing mature olfactory neurons within this circuitry. However, the role of PrP^C on each specific adult neurogenic processes remains to be investigated in detail. To tease out the subtle effects of prion prote

SUBMITTER: Parrie LE 

PROVIDER: S-EPMC6984647 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature