A comparative study of the efficacy of NAXOZOL compared to celecoxib in patients with osteoarthritis.

ABSTRACT:

Objective

Selective cyclooxygenase-2 inhibitors (celecoxib) can minimize the gastrointestinal complications related to non-steroidal anti-inflammatory drug (NSAID) use. NAXOZOL is a new combination formulation designed to provide sequential delivery of a non-enteric-coated, immediate-release esomeprazole strontium tetrahydrate 20 mg mantle followed by an enteric-coated naproxen 500 mg core. However, there have been no studies comparing NAXOZOL to celecoxib with respect to gastrointestinal tract protection and pain relief in patients with osteoarthritis. This study was undertaken to compare the effects of NAXOZOL and celecoxib with respect to gastrointestinal tract protection and pain relief in patients with osteoarthritis.

Methods

The randomized enrolled patients were divide

SUBMITTER: Park MS 

PROVIDER: S-EPMC6984721 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature