Metabolomic Analysis of the Effects of Leptin Replacement Therapy in Patients with Lipodystrophy.

ABSTRACT:

Context and objective

Leptin treatment has dramatic clinical effects on glucose and lipid metabolism in leptin-deficient patients with lipodystrophy. Further elucidation of metabolic effects of exogenous leptin therapy will shed light on understanding leptin physiology in humans. Our objective was to utilize metabolomic profiling to examine the changes associated with administration of short-term metreleptin therapy in patients with lipodystrophy.

Study design

We conducted a pre-post-treatment study in 19 patients (75% female) with varying forms of lipodystrophy (congenital generalized lipodystrophy, n = 10; acquired generalized lipodystrophy, n = 1; familial partial lipodystrophy, n = 8) who received daily subcutaneous metreleptin injections for a period of 16 to 23 weeks.

SUBMITTER: Grewal S 

PROVIDER: S-EPMC6984783 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature