Construction of a long non‑coding RNA‑mediated transcription factor and gene regulatory triplet network reveals global patterns and biomarkers for ischemic stroke.

ABSTRACT: Ischemic stroke (IS) is a severe neurological disease and a major cause of death and disability throughout the world. A long non‑coding (lnc)RNA, transcription factor (TF) and gene can form a lncRNA‑mediated regulatory triplet (LncMRT), which is a functional network motif that regulates numerous aspects of human diseases. However, systematic identification and molecular characterization of LncMRTs and their roles in IS has not been carried out. In the present study, a global LncMRT network was constructed and the topological features were characterized based on experimentally verified interactions. An integrated approach was developed to identify significantly dysregulated LncMRTs in peripheral blood mononuclear cells of IS and these dysregulated LncMRT networks exhibited specific topologi

SUBMITTER: Cao Y 

PROVIDER: S-EPMC6984793 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature