HIV-1 second-line failure and drug resistance at high-level and low-level viremia in Western Kenya.

ABSTRACT: OBJECTIVE:Characterize failure and resistance above and below guidelines-recommended 1000 copies/ml virologic threshold, upon second-line failure. DESIGN:Cross-sectional study. METHODS:Kenyan adults on lopinavir/ritonavir-based second-line were enrolled at AMPATH (Academic Model Providing Access to Healthcare). Charts were reviewed for demographic/clinical characteristics and CD4/viral load were obtained. Participants with detectable viral load had a second visit and pol genotyping was attempted in both visits. Accumulated resistance was defined as mutations in the second, not the first visit. Low-level viremia (LLV) was detectable viral load less than 1000 copies/ml. Failure and resistance associations were evaluated using logistic and Poisson regression, Fisher Exact and t-tests. RESULTS

SUBMITTER: Kantor R 

PROVIDER: S-EPMC6984814 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature