Urinary microbiome associated with chronic allograft dysfunction in kidney transplant recipients.

ABSTRACT:

Background

We performed a study to identify differences in the urinary microbiome associated with chronic allograft dysfunction (CAD) and compared the urinary microbiome of male and female transplant recipients with CAD.

Methods

This case-control study enrolled 67 patients within the Deterioration of Kidney Allograft Function (DeKAF) Genomics cohort at two transplant centers. CAD was defined as a greater than 25% rise in serum creatinine relative to a 3 month post-transplant baseline. Urine samples from patients with and without CAD were analyzed using 16S V4 bacterial ribosomal DNA sequences.

Results

Corynebacterium was more prevalent in female and male patients with CAD compared to non-CAD female patients (P = 0.0005). A total 21 distinct Operational Taxonomic Unit

SUBMITTER: Wu JF 

PROVIDER: S-EPMC6984979 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature