Heat shock protein 27 as a predictor of prognosis in patients admitted to hospital with acute COPD exacerbation.

ABSTRACT: Episodes of acute exacerbations are major drivers of hospitalisation and death from COPD. To date, there are no objective biomarkers of disease activity or biomarkers to predict patient outcome. In this study, 211 patients hospitalised for an acute exacerbation of COPD have been included. At the time of admission, routine blood tests have been performed including complete blood count, C-reactive protein, cardiac troponin T and NT-proBNP. Heat shock protein 27 (HSP27) serum concentrations were determined at time of admission, discharge and 180 days after discharge by ELISA. We were able to demonstrate significantly increased HSP27 serum concentrations in COPD patients at time of admission to hospital as compared to HSP27 concentrations obtained 180 days after discharge. In univariable Cox r

SUBMITTER: Zimmermann M 

PROVIDER: S-EPMC6985059 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature