Mismatch repair protein loss in breast cancer: clinicopathological associations in a large British Columbia cohort.

ABSTRACT:

Purpose

Alterations to mismatch repair (MMR) pathways are a known cause of cancer, particularly colorectal and endometrial carcinomas. Recently, checkpoint inhibitors have been approved for use in MMR-deficient cancers of any type (Prasad et al. in JAMA Oncol 4:157-158, 2018). Functional studies in breast cancer have shown associations between MMR loss, resistance to aromatase inhibitors and sensitivity to palbociclib (Haricharan et al. in Cancer Discov 7:1168-1183, 2017). Herein, we investigate the clinical meaning of MMR deficiency in breast cancer by immunohistochemical assessment of MSH2, MSH6, MLH1 and PMS2 on a large series of breast cancers linked to detailed biomarker and long-term outcome data.

Methods

Cases were classified as MMR intact when all four markers expres

SUBMITTER: Cheng AS 

PROVIDER: S-EPMC6985067 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature