Resting-state connectivity stratifies premanifest Huntington's disease by longitudinal cognitive decline rate.

ABSTRACT: Patient stratification is critical for the sensitivity of clinical trials at early stages of neurodegenerative disorders. In Huntington's disease (HD), genetic tests make cognitive, motor and brain imaging measurements possible before symptom manifestation (pre-HD). We evaluated pre-HD stratification models based on single visit resting-state functional MRI (rs-fMRI) data that assess observed longitudinal motor and cognitive change rates from the multisite Track-On HD cohort (74 pre-HD, 79 control participants). We computed longitudinal performance change on 10 tasks (including visits from the preceding TRACK-HD study when available), as well as functional connectivity density (FCD) maps in single rs-fMRI visits, which showed high test-retest reliability. We assigned pre-HD subjects to sub

SUBMITTER: Polosecki P 

PROVIDER: S-EPMC6985137 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature