Ontology highlight
ABSTRACT:
SUBMITTER: Mosaheb MM
PROVIDER: S-EPMC6985231 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Mosaheb Mubeen M MM Dobrikova Elena Y EY Brown Michael C MC Yang Yuanfan Y Cable Jana J Okada Hideho H Nair Smita K SK Bigner Darell D DD Ashley David M DM Gromeier Matthias M
Nature communications 20200127 1
Viruses naturally engage innate immunity, induce antigen presentation, and mediate CD8 T cell priming against foreign antigens. Polioviruses can provide a context optimal for generating antigen-specific CD8 T cells, as they have natural tropism for dendritic cells, preeminent inducers of CD8 T cell immunity; elicit Th1-promoting inflammation; and lack interference with innate or adaptive immunity. However, notorious genetic instability and underlying neuropathogenicity has hampered poliovirus-ba ...[more]