Porcine CXCR1/2 antagonist CXCL8_(3-72)G31P inhibits lung inflammation in LPS-challenged mice.

ABSTRACT: Swine pneumonia is a great threat for pig industry around the world, which is usually accompanied with neutrophils infiltration in the airway. Although interleukin-8 (CXCL8) and its receptors, CXC chemokine receptor 1 and 2 (CXCR1/2) in human have been well documented, the expression and function of CXCR1/2 is still unknown in swine. To explore the feasibility to develop new veterinary anti-inflammatory drugs targeting porcine CXCR1/2, we detected CXCR1/2 expression in swine pneumonia through Real-Time PCR and immunohistochemistry for the first time. Two porcine CXCR1/2 antagonists, CXCL8_(3-72)N11R/G31P (pN11R) and CXCL8_(3-72)G31P (pG31P) were prepared and their anti-inflammatory effects were evaluated using cell chemotaxis assays and animal experiments. Our data show

SUBMITTER: Wang X 

PROVIDER: S-EPMC6985246 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature