Photosynthesis-inspired H₂ generation using a chlorophyll-loaded liposomal nanoplatform to detect and scavenge excess ROS.

ABSTRACT: A disturbance of reactive oxygen species (ROS) homeostasis may cause the pathogenesis of many diseases. Inspired by natural photosynthesis, this work proposes a photo-driven H₂-evolving liposomal nanoplatform (Lip NP) that comprises an upconversion nanoparticle (UCNP) that is conjugated with gold nanoparticles (AuNPs) via a ROS-responsive linker, which is encapsulated inside the liposomal system in which the lipid bilayer embeds chlorophyll a (Chla). The UCNP functions as a transducer, converting NIR light into upconversion luminescence for simultaneous imaging and therapy in situ. Functioning as light-harvesting antennas, AuNPs are used to detect the local concentration of ROS for FRET biosensing, while the Chla activates the photosynthesis of H₂ gas to scavenge loca

SUBMITTER: Wan WL 

PROVIDER: S-EPMC6985250 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature