Molecular Links Between Angiogenesis and Neuroendocrine Phenotypes in Prostate Cancer Progression.

ABSTRACT: As a common therapy for prostate cancer, androgen deprivation therapy (ADT) is effective for the majority of patients. However, prolonged ADT promotes drug resistance and progression to an aggressive variant with reduced androgen receptor signaling, so called neuroendocrine prostate cancer (NEPC). Until present, NEPC is still poorly understood, and lethal with no effective treatments. Elevated expression of neuroendocrine related markers and increased angiogenesis are two prominent phenotypes of NEPC, and both of them are positively associated with cancers progression. However, direct molecular links between the two phenotypes in NEPC and their mechanisms remain largely unclear. Their elucidation should substantially expand our knowledge in NEPC. This knowledge, in turn, would facilitate t

SUBMITTER: Wang Z 

PROVIDER: S-EPMC6985539 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature