Store-Operated Calcium Entry via STIM1 Contributes to MRGPRX2 Induced Mast Cell Functions.

ABSTRACT: Mast cells are inflammatory immune cells that play an essential role in mediating allergic reactions in humans. It is well-known that mast cell activation is critically regulated by intracellular calcium ion (Ca²⁺) concentrations. MAS-related G-protein coupled receptor-X2 (MRGPRX2) is a G-protein coupled receptor (GPCR) expressed on mast cells that is activated by various ligands, including several FDA approved drugs; consequently, this receptor has been implicated in causing pseudo-allergic reactions in humans. MRGPRX2 activation leads to an increase in intracellular Ca²⁺ levels; however, the Ca²⁺ mobilizing mechanisms utilized by this receptor are largely unknown. Previous reports showed that store-operated Ca²⁺ entry (SOCE) via the calcium sen

SUBMITTER: Occhiuto CJ 

PROVIDER: S-EPMC6985555 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature