Geometry of the Carotid Artery and Its Association With Pathologic Changes in a Chinese Population.

ABSTRACT:

Objectives

Carotid artery geometry influences blood flow disturbances and is thus an important risk factor for carotid atherosclerosis. Extracellular matrix (ECM) and yes-associated protein (YAP) expression may play essential roles in the pathophysiology of carotid artery stenosis, but the effect of blood flow disturbances of carotid bifurcation location on the ECM is unknown. We hypothesized that carotid artery anatomy and geometry are independently associated with the ECM and YAP expression.

Methods

In this cross-sectional study, 193 patients were divided into two groups: an asymptomatic group (n = 111) and a symptomatic group (n = 82), symptomatic patients presenting with ischemic attack, amaurosis fugax, or minor non-disabling stroke. For all subjects befor

SUBMITTER: Cui Y 

PROVIDER: S-EPMC6985580 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature