In Vitro Susceptibility Testing of GSK656 against Mycobacterium Species.

ABSTRACT: In this study, we aimed to assess the in vitro susceptibility to GSK656 among multiple mycobacterial species and to investigate the correlation between leucyl-tRNA synthetase (LeuRS) sequence variations and in vitro susceptibility to GSK656 among mycobacterial species. A total of 187 mycobacterial isolates, comprising 105 Mycobacterium tuberculosis isolates and 82 nontuberculous mycobacteria (NTM) isolates, were randomly selected for the determination of in vitro susceptibility. For M. tuberculosis, 102 of 105 isolates had MICs of ≤0.5 mg/liter, demonstrating a MIC₅₀ of 0.063 mg/liter and a MIC₉₀ of 0.25 mg/liter. An epidemiological cutoff value of 0.5 mg/liter was proposed for identification of GSK656-resistant M. tuberculosis

SUBMITTER: Dong W 

PROVIDER: S-EPMC6985724 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature