Dissecting erm(41)-Mediated Macrolide-Inducible Resistance in Mycobacterium abscessus.

ABSTRACT: Macrolides are the cornerstone of Mycobacterium abscessus multidrug therapy, despite that most patients respond poorly to this class of antibiotics due to the inducible resistance phenotype that occurs during drug treatment. This mechanism is driven by the macrolide-inducible ribosomal methylase encoded by erm(41), whose expression is activated by the transcriptional regulator WhiB7. However, it has been debated whether clarithromycin and azithromycin differ in the extent to which they induce erm(41)-mediated macrolide resistance. Herein, we show that macrolide resistance is induced more rapidly in various M. abscessus isolates upon exposure to azithromycin than to clarithromycin, based on MIC determination. Macrolide-induced expression of erm(41) was assessed in vivo using a strain carryi

SUBMITTER: Richard M 

PROVIDER: S-EPMC6985735 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature