Differences in the Pharmacokinetics of Gentamicin between Oncology and Nononcology Pediatric Patients.

ABSTRACT: Dosing gentamicin in pediatric patients can be difficult due to its narrow therapeutic index. A significantly higher percentage of fat mass has been observed in children receiving oncology treatment than in those who are not. Differences in the pharmacokinetics of gentamicin between oncology and nononcology pediatric patients and individual dosage requirements were evaluated in this study, using normal fat mass (NFM) as a body size descriptor. Data from 423 oncology and 115 nononcology patients were analyzed. Differences in drug disposition were observed between the oncology and nononcology patients, with oncology patients having a 15% lower central volume of distribution and 32% lower intercompartmental clearance. Simulations based on the population pharmacokinetic model demonstrated low

SUBMITTER: Llanos-Paez CC 

PROVIDER: S-EPMC6985741 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature