Clinical value of non-coding RNAs in cardiovascular, pulmonary, and muscle diseases.

ABSTRACT: Although a majority of the mammalian genome is transcribed to RNA, mounting evidence indicates that only a minor proportion of these transcriptional products are actually translated into proteins. Since the discovery of the first non-coding RNA (ncRNA) in the 1980s, the field has gone on to recognize ncRNAs as important molecular regulators of RNA activity and protein function, knowledge of which has stimulated the expansion of a scientific field that quests to understand the role of ncRNAs in cellular physiology, tissue homeostasis, and human disease. Although our knowledge of these molecules has significantly improved over the years, we have limited understanding of their precise functions, protein interacting partners, and tissue-specific activities. Adding to this complexity, it remain

SUBMITTER: Bonnet S 

PROVIDER: S-EPMC6985837 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature