Meta-analysis of blood genome-wide expression profiling studies in pulmonary arterial hypertension.

ABSTRACT: Inflammatory cell infiltrates are a prominent feature of aberrant vascular remodeling in pulmonary arterial hypertension (PAH), suggesting that immune effector cells contribute to disease progression. Genome-wide blood expression profiling studies have attempted to better define this inflammatory component of PAH pathobiology but have been hampered by small sample sizes, methodological differences, and very little gene-level reproducibility. The current meta-analysis (seven studies; 156 PAH patients/110 healthy controls) was performed to assess the comparability of data across studies and to possibly derive a generalizable transcriptomic signature. Idiopathic (IPAH) compared with disease-associated PAH (APAH) displayed highly similar expression profiles with no differentially expressed gen

SUBMITTER: Elinoff JM 

PROVIDER: S-EPMC6985867 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature