Surfactant plus budesonide decreases lung and systemic responses to injurious ventilation in preterm sheep.

ABSTRACT: Mechanical ventilation from birth with normal tidal volumes (V_T) causes lung injury and systemic responses in preterm sheep. The addition of budesonide to surfactant therapy decreases these injury markers. Budesonide and surfactant will decrease the injury from injurious V_T ventilation in preterm sheep. Lambs at 126 ± 1 day gestational age were ventilated from birth with either: 1) Normal V_T [surfactant 200 mg/kg before ventilation, positive end expiratory pressure (PEEP) 5 cmH₂O, V_T 8 mL/kg] or 2) Injury V_T (high pressure, 100% oxygen, no PEEP) for 15 min, then further randomized to surfactant + saline or surfactant + 0.25 mg/kg budesonide with Normal V_T for 6 h. Lung function and lung, liver, and brain tissues w

SUBMITTER: Hillman NH 

PROVIDER: S-EPMC6985873 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature