Extracellular Myocardial Volume in Patients With Aortic Stenosis.

ABSTRACT:

Background

Myocardial fibrosis is a key mechanism of left ventricular decompensation in aortic stenosis and can be quantified using cardiovascular magnetic resonance (CMR) measures such as extracellular volume fraction (ECV%). Outcomes following aortic valve intervention may be linked to the presence and extent of myocardial fibrosis.

Objectives

This study sought to determine associations between ECV% and markers of left ventricular decompensation and post-intervention clinical outcomes.

Methods

Patients with severe aortic stenosis underwent CMR, including ECV% quantification using modified Look-Locker inversion recovery-based T1 mapping and late gadolinium enhancement before aortic valve intervention. A central core laboratory quantified CMR parameters.

Results

SUBMITTER: Everett RJ 

PROVIDER: S-EPMC6985897 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature